Yes, but it’s risky for your main PC. You can mount the ISO and run setup.exe to upgrade your current Windows installation. For a clean install, a USB/DVD is still best.
A is a complete, bit-for-bit copy of the Windows operating system installation disc, bundled into a single archive file. The name "ISO" comes from the ISO 9660 file system standard used by optical discs (CDs, DVDs, Blu-rays). what is windows iso file
– A fundamental utility for modern computing. Yes, but it’s risky for your main PC