| Poison | Fatal dose | Signs & symptoms | Antidote | Medicolegal aspect | |--------|------------|------------------|----------|--------------------| | | variable | Salivation, lacrimation, miosis, convulsions | Atropine + Pralidoxime | Insecticide poisoning – often accidental/suicidal | | Opioids (morphine, heroin) | 200 mg | Coma, pinpoint pupil, respiratory depression | Naloxone | Injections marks, drug abuse | | Barbiturates | 2–5 g | CNS depression, hypothermia | Supportive + activated charcoal | Suicide common | | Alcohol (ethanol) | 5–8 g/kg | Ataxia, slurred speech, coma | Supportive | Drunkenness, DUI | | Paracetamol | 10–15 g | Liver failure (after 48–72 hrs) | N-acetylcysteine | Suicidal overdose | | Cyanide | 200 mg | Sudden collapse, bitter almond smell | Amyl nitrite + sodium thiosulfate | Homicidal use | | Corrosives (acid/alkali) | variable | Oral burns, stricture esophagus | Avoid emesis | Accidental in children | | Heavy metals (arsenic, lead) | variable | Rice water stools (As), lead line (Pb) | Chelation | Chronic poisoning |
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