Creative Cloud System Requirements ((install)) -

Adobe offers a free “Creative Cloud Desktop” app install; it will check your system and warn if any installed app can’t run.

A: Adobe strongly advises against this. While you can technically move some cache files, the core applications must be installed on the internal boot drive (C: drive or Macintosh HD) to function reliably. creative cloud system requirements

However, there is a required to run the desktop app and the most popular tools like Photoshop, Illustrator, and Premiere Pro. Adobe offers a free “Creative Cloud Desktop” app