The story picks up seven years after the events of the fourth season. Michael Scofield (played by Wentworth Miller) is presumed dead, and Lincoln Burrows (played by Dominic Purcell) is still on the run. The new season introduces a new character, Jaimee Monroe (played by Paola Merín), a federal agent tasked with capturing Lincoln.
The central mystery reveals that Michael's "death" in the series finale, The Final Break , was a ruse forced upon him by a rogue CIA operative known as (later revealed as Jacob Anton Ness, the new husband of Sara Tancredi ). To protect his family, Michael was blackmailed into working for a shadow organization called 21 Void , breaking high-value targets out of international prisons. The Escape from Yemen prison break season 5 synopsis
| Element | Detail | | :--- | :--- | | | April 4 – May 30, 2017 | | Number of Episodes | 9 | | Main Villain | Poseidon (CIA Agent Aram Highmore) | | Primary Setting | Ogygia Prison, Sana’a, Yemen | | Michael’s Alias | Kaniel Outis (linked to Homer’s “Outis” = “Nobody”) | | Central Twist | Michael faked his death in Season 4 to go undercover. | The story picks up seven years after the
Throughout the season, the characters face unexpected twists and turns, including: The central mystery reveals that Michael's "death" in
The fifth season of Prison Break picks up nine years after the events of the original series. Michael Scofield, presumed dead, is revealed to be alive in a heavily fortified prison in Yemen. The story follows Michael, who has been imprisoned for his role in the escape from Fox River State Penitentiary. Michael's brother, Lincoln, now a U.S. Senator, teams up with former allies, including Sara Tancredi (Sarah Wayne Callies) and Paul Kellerman (Paul Adelstein), to rescue Michael.